Classification of lymphoid neoplasms: the microscope as a tool for disease discovery
摘要：
In the past 50 years, we have witnessed explosive growth in the understanding of normal and neoplastic lymphoid cells. B-cell, T-cell, and natural killer (NK)–cell neoplasms in many respects recapitulate normal stages of lymphoid cell differentiation and function, so that they can be to some extent classified according to the corresponding normal stage. Likewise, the molecular mechanisms involved the pathogenesis of lymphomas and lymphoid leukemias are often based on the physiology of the lymphoid cells, capitalizing on deregulated normal physiology by harnessing the promoters of genes essential for lymphocyte function. The clinical manifestations of lymphomas likewise reflect the normal function of lymphoid cells in vivo. The multiparameter approach to classification adopted by the World Health Organization (WHO) classification has been validated in international studies as being highly reproducible, and enhancing the interpretation of clinical and translational studies. In addition, accurate and precise classification of disease entities facilitates the discovery of the molecular basis of lymphoid neoplasms in the basic science laboratory.
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关键词：
Humans Hodgkin Disease Hematologic Neoplasms Microscopy Molecular Diagnostic Techniques Immunologic Tests Lymphoma, B-Cell, Marginal Zone Models, Biological World Health Organization
DOI：
10.1182/blood-2008-07-077982
被引量：
年份：
2008
Elsevier
万方医学
Semantic Scholar
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掌桥科研
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