Effect of butyrolactone and gamma-hydroxybutyrate on the EEG and sleep cycle in man.
摘要:
The purpose of the present paper is to compare a sleep state induced by butyrolactone and sodium γ-hydroxybutyrate with natural sleep in man with the aids of the EEG, electro-oculogram and EMG of the mental muscle. The following results were obtained: 1. (1) The i.v. administration of 20–30 mg/kg of butyrolactone and sodium γ-hydroxybutyrate induced in man a peculiar state without marked change in consciousness and with high voltage slow waves in the EEG. 2. (2) When butyrolactone was administered at night, just prior to bed-time, the spindle and delta stages of sleep occurred earlier, the duration of the spindle stage became shorter and the delta stage tended to last longer than in the control night. The latency to the onset of the initial REM period calculated either from the start of the injection or from the onset of sleep did not differ significantly.
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DOI:
10.1016/0013-4694(67)90064-8
被引量:
年份:
1967
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