摘要：

The aim of this study was to determine in spontaneously hypertensive () whether a significant association may be observed between the low-frequency component of blood pressure variability () and arterial distensibility and to evaluate the role of the autonomic nervous system in this relationship. (1 mg/kg/d s.c.), flesinoxan (1 mg/kg/d s.c.), and (30 mg/kg/d s.c.) were infused over 24 h in . Blood pressure was recorded in conscious and was characterized by spectral analysis. The distensibility-pressure curves for the carotid artery were determined by an ultrasonic echo-tracking device in anesthetized . Untreated had higher mean arterial pressure (MAP) and low-frequency MAP but a lower distensibility than normotensive Wistar-Kyoto . In inhibition of the autonomic nervous system by peripheral blockade of -adrenoceptors (, 1 mg/kg, or , 30 mg/kg) or centrally mediated reduction of sympathetic tone (flesinoxan, 1 mg/kg) reduced MAP and low-frequency MAP in the conscious state and increased carotid operational distensibility in the anesthetized state. In these , we observed a negative association between low-frequency MAP and operational distensibility ( r = -0.48, p < 0.01). From multiple regression analysis, MAP and low-frequency MAP, but not drug treatment, influenced arterial distensibility. Our study in provides evidence for a strong association between increased low-frequency MAP and reduced arterial distensibility, with a common modulation provided by the autonomic nervous system via the alpha 1 -adrenergic receptor component and central nervous system.

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