r-Imino Esters: Versatile Substrates for the Catalytic, Asymmetric Synthesis of r- and β-Amino Acids and β-Lactams
摘要：
The catalytic asymmetric addition of organic nucleophiles to α-imino esters has emerged as one of the most promising and intensely investigated routes to optically enriched α- and β-amino acid derivatives and β-lactams. The importance of α-imino esters stems not only from the vast appeal of the potential product classes,1 but also from their remarkable reactivity as highly electrophilic imines. With each passing year, the number of publications concerning the asymmetric alkylation of imino esters grows significantly. The asymmetric alkylation of imines2 and N,O-acetals has been in itself a subject of intense interest.3 In this Account, we wish to illustrate our contribution to this timely field, as well as to highlight the seminal contributions of others.
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DOI：
10.1002/chin.200316293
被引量：
年份：
2003
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