NF-kappaB at the crossroads of life and death.
摘要：
The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial antigens are selected to survive and proliferate in response to infection, whereas those that are self-reactive are eliminated via apoptosis. Even the survival of alloreactive T cells requires their proper costimulation and, when infection subsides, the activated T cells are eliminated. A major regulator of such life or death decisions is the transcription factor NF-kappaB. However, NF-kappaB cannot function alone. A variety of mechanisms exist to modulate its activity and thereby affect the ultimate outcome of a cell's fate.
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关键词：
Animals Humans TNF Receptor-Associated Factor 1 TNF Receptor-Associated Factor 2 Proteins NF-kappa B Apoptosis Tumor Necrosis Factor-alpha Immunity Inhibitor of Apoptosis Proteins
DOI：
10.1134/S0021364008210054
被引量：
年份：
2002
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