Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes
摘要：
Recombinant human IL-6 (rhIL-6) is a potent inducer of the synthesis of acute phase proteins in adult human hepatocytes. A wide spectrum of acute phase proteins is regulated by this mediator. After labeling of rhIL-6 stimulated human hepatocytes with [35S]methionine acute phase protein synthesis was measured by immunoprecipitation. Serum amyloid A, C-reactive protein, haptoglobin, α1-antichymotrypsin and fibrinogen were strongly induced (26-, 23-, 8.6-, 4.6- and 3.8-fold increases, respectively). Moderate increases were found for α1-antitrypsin (2.7-fold) and α1-acid glycoprotein (2.7-fold). RhIL-6 had no effect on α1-macroglobulin, whereas fibronectin, albumin and transferrin decreased to 64, 56 and 55% of controls. In the cases of serum amyloid A, haptoglobin, α1-antichymotrypsin, α1-antitrypsin and α1-acid glycoprotein, dexamethasone enhanced the action of rhIL-6. We conclude that rhIL-6 controls the acute phase response in human liver cells.
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关键词：
BSF-2, B-cell stimulatory factor 2 HSF, hepatocyte-stimulating factor IL-6, interleukin-6 rhIL-6, recombinant human interleukin-6
DOI：
10.1016/0014-5793(88)80766-x
被引量：
年份：
1988
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