Physiology of microglial cells
摘要：
Microglial cells in culture and in situ express a defined pattern of K + channels, which is distinct from that of other glial cells and neurons. This pattern undergoes defined changes with microglial activation. As expected for a cell with immunological properties, microglia express a variety of cytokine and chemokine receptors, which are linked to the mobilization of Ca 2+ (cytosolic free calcium) from internal stores. Microglial cells also have the capacity to respond to neuronal activity: they express receptors for the major excitatory receptor glutamate and the main inhibitory receptor GABA (γ-amino butyric acid). By expressing purinergic receptors, microglia can sense astrocyte activity in the form of Ca 2+ waves. Activation of transmitter receptors can affect cytokine release which is a potential means as to how brain activity can affect immune function.
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DOI：
10.1016/j.brainresrev.2004.12.003
被引量：
年份：
2005
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