Sustained release indomethacin

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申请(专利)号：

US19780968608

申请日期：

1978-12-11

公开/公告号：

US4173626A

公开/公告日期：

1979-11-06

申请(专利权)人：

MERCK & CO INC

发明人：

RE Dempski，GN Mehta，JC Saboe

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被引量：

289

摘要：

A sustained release indomethacin pharmaceutical product is provided that utilizes a pellet formulation encapsulated in a hard gelatin capsule. A portion of the pellets is uncoated for immediate and rapid release of indomethacin for elevating the plasma level. The remainder of the pellets are coated with a polymer to sustain the plasma level. The uncoated and coated pellets may be mixed with non-medicated pellets as a capsule filler.

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