Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo.
摘要：
Previous studies have indicated that Bcl-3 interacts through its ankyrin repeats with the transcriptional factors NF-kappaB1 (p50) and NF-kappaB2 (p52), affecting their biological activities. To further investigate the role of Bcl-3 in vivo and its association with the NF-kappaB proteins, we have generated transgenic mice constitutively expressing Bcl-3 in thymocytes. The results indicate that Bcl-3 is associated with endogenous p50 and p52 in nuclear extracts from transgenic animals. Remarkably, constitutive expression of Bcl-3 in these cells augments the DNA binding activity of p52 homodimers. This effect could be reproduced in vitro and is blocked by anti-Bcl-3 antibodies. We have also shown that Bcl-3 is phosphorylated in thymocytes and that its dephosphorylation greatly decreases the effect on p50 homodimers.
展开
DOI：
10.1128/MCB.16.4.1342
被引量：
年份：
1996
BMJ
国家科技图书文献中心
(权威机构)
Wiley
万方
万方医学
查看更多
掌桥科研
Pubmed Central
(全网免费下载)
NCBI
Europe PMC
(全网免费下载)
Europe PMC
NCBI
JBC
AACR
ResearchGate
(全网免费下载)
ResearchGate
Citeseer
(全网免费下载)
EBSCO
jacionline.org
onAcademic
mendeley.com
mysciencework.com
jimmunol.org
mcb.asm.org
jem.rupress.org
emboj.embopress.org
fasebj.org
bloodjournal.org
core.ac.uk
www.socolar.com
deepdyve.com
genesdev.cshlp.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
