Synthesis and biological activity of spiro[isocoumarin-piperidines] and related compounds. I
摘要：
1'-Alkylspiro [isochroman-3, 4'-piperidin]-1-ones (2) and 1'-alkylspiro [isochroman-4, 4'-piperidines] (4 and 5) were prepared and examined for analgesic activity. Several of the 4-spiro compounds (3, 4, and 5) were found to have analgesic activity as potent as that of aminopyrine, while the 3-spiro compounds (2) were inactive. Further pharmacological studies revealed that several of these compounds inhibited the histamine release induced by compound 48/80 from isolated rat peritoneal mast cells.
展开
关键词：
isocoumarin isochroman piperidine analgesic activity histaminerelease inhibition structure-activity relationship spiro compound
DOI：
10.1248/cpb.29.402
被引量：
年份：
1981
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
