CD4+ CD25+ suppressor T cells: more questions than answers.
摘要：
Several mechanisms control discrimination between self and non-self, including the thymic deletion of autoreactive T cells and the induction of anergy in the periphery. In addition to these passive mechanisms, evidence has accumulated for the active suppression of autoreactivity by a population of regulatory or suppressor T cells that co-express CD4 and CD25 (the interleukin-2 receptor alpha-chain). CD4+ CD25+ T cells are powerful inhibitors of T-cell activation both in vivo and in vitro. The enhancement of suppressor-cell function might prove useful for the treatment of immune-mediated diseases, whereas the downregulation of these cells might be beneficial for the enhancement of the immunogenicity of vaccines that are specific for tumour antigens.
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关键词：
Thymus Gland Antigen-Presenting Cells Animals Humans Mice Rats Transforming Growth Factor beta Receptors, Interleukin-2 Antigens, CD4 Antigens, Differentiation
DOI：
10.1038/nri821
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年份：
2002
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