摘要：

The densitometric analytic procedure used for can also be used to quantify its desmethyl metabolite. In a study involving six healthy male volunteers, tablets were shown to be as bioavailable as a solution of . After administration of a single dose of 20 mg, peak serum levels of were 42 ng/ml; those of the metabolite were 12 ng/ml. The half-lives of the drug and metabolite were approximately 4 and 9 days, respectively, after a single dose. After three widely separated single doses, a reversible increase in elimination half-life occurred.

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