Studies on the permeability of the blood-retinal barrier. II. Breakdown of the blood-retinal barrier by injury.
摘要：
The interendothelial junctions of retinal and iris vessels have been surveyed and compared in a number of animals. Thorium dioxide particles were also injected into the circulation to investigate their passage through these junctions when the eye was submitted to paracentesis or local application of histamine. The junctions between the endothelial cells of the retinal vessels constantly showed a continuous zonula occludens as the predominant feature of their junctional complexes, reinforced occasionally by a desmosomal component. In these junctions the injected particles were always arrested at the side facing the lumen, and the outer leaflets of the plasma membranes of the endothelial cells remained fused together in an intermediate line even when the eye was submitted to paracentesis, local application of histamine, or when the endothelial cells were made highly swollen or shrunken. By contrast, the interendothelial junctions of the iris vessels which showed a discontinuous zonula occludens were seen to open after local application of histamine and when the intraocular pressure was drastically lowered by paracentesis. The significance of these findings is discussed and it is considered that the junctional complexes of the retinal vessels play an important role in the mechanism of the blood-retinal barrier.
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DOI：
10.1016/S0014-4835(66)80011-8
被引量：
年份：
1966
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