Methods for using persistent gases as ultrasound contrast media

阅读量:

17

申请(专利)号:

08/382253

申请日期:

02/01/1995

公开/公告号:

US5558094

公开/公告日期:

09/24/1996

申请(专利权)人:

Sonus Pharmaceuticals, Inc. (Bothell, WA)

发明人:

Quay, Steven M

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被引量:

156

摘要:

Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.

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