Nucleosides. XVIII. Synthesis of 2'-Fluorothymidine, 2'-Fluorodeoxyuridine, and Other 2'-Halogeno-2'-Deoxy Nucleosides1,2
摘要：
The reaction of 2,2′-anhydro nucleosides with anhydrous hydrogen halides gave 2′-halogeno-2′-deoxy nucleosides in good yields. By this reaction the 2′-fluoro, 2′-chloro, and 2′-bromo analogs of deoxyuridine [VIIa(F), VIIa(Cl), VIIa(Br)] and of thymidine [VIIb(F), VIIb(Cl), VIIb(Br)] were synthesized. The 2′-fluoro analog of 5-fluorodeoxyuridine [VIIc(F)] was prepared. Comparison was made of the stability of the 2′-halogenodeoxyuridine derivatives in alkali, acid, and upon heating.
展开
DOI：
10.1021/jo01026a009
被引量：
年份：
1964
相似文献
参考文献
引证文献
辅助模式
0
引用
文献可以批量引用啦~
欢迎点我试用！
