Amino acids and peptides. XIX. Preparation of enkephalin-poly(ethylene glycol) hybrid and evaluation of its analgesic activity.
摘要：
The poly(ethylene glycol) hybrid of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) was prepared and its analgesic activity was examined. Poly(ethylene glycol) #4000 was converted to amino-poly(ethylene glycol) and coupled with the N alpha-protected pentapeptide, followed by trifluoroacetic acid treatment to give the hybrid. The hybrid was soluble in water or various organic solvents. The analgesic activity of Leu-enkephalin was markedly potentiated by hybrid formation with poly(ethylene glycol).
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DOI：
10.1248/cpb.41.2053
被引量：
年份：
1993
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