Erythrocyte P antigen: cellular receptor for B19 parvovirus
摘要：
The pathogenic human parvovirus B19 replicates only in erythroid progenitor cells. This virus was shown to bind to blood-group P antigen, as measured by hemagglutination. Erythrocytes lacking P antigen were not agglutinated with B19. Purified P antigen (globoside) blocked the binding of the virus to erythroid cells and the infectivity of the virus in a hematopoietic colony assay. Target cells were protected from infection by preincubation with monoclonal antibody to globoside. Knowledge of a parvovirus receptor has implications for understanding the pathogenesis of parvovirus infections and for the use of parveviruses in gene therapy.
展开
关键词：
Humans Parvovirus B19, Human Capsid Globosides Antibodies, Monoclonal P Blood-Group System Phenotype Hemagglutination Molecular Sequence Data Erythroid Precursor Cells
DOI：
10.1126/science.8211117
被引量：
年份：
1993
BMJ
Semantic Scholar
万方医学
Europe PMC
NCBI
查看更多
Oxford Univ Press
NCBI
JSTOR
dialnet.unirioja.es
adsabs.harvard.edu
ResearchGate
ProQuest
EBSCO
jasn.asnjournals.org
sciencemag.org
SAGE
highbeam.com
onAcademic
scienceopen.com
bbmt.org
cmr.asm.org
scindeks.ceon.rs
antimicrobe.org
nejm.org
mendeley.com
asheducationbook.hematologylibrary.org
go.galegroup.com
jci.org
pubfacts.com
circ.ahajournals.org
bloodjournal.org
www.socolar.com
ganino.com
(全网免费下载)
ganino.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
