A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans.
摘要：
To maintain genomic stability following DNA damage, multicellular organisms activate checkpoints that induce cell cycle arrest or apoptosis. Here we show that genotoxic stress blocks cell proliferation and induces apoptosis of germ cells in the nematode C. elegans. Accumulation of recombination intermediates similarly leads to the demise of affected cells. Checkpoint-induced apoptosis is mediated by the core apoptotic machinery (CED-9/CED-4/CED-3) but is genetically distinct from somatic cell death and physiological germ cell death. Mutations in three genes— mrt-2, which encodes the C. elegans homolog of the S. pombe rad1 checkpoint gene, rad-5, and him-7—block both DNA damage-induced apoptosis and cell proliferation arrest. Our results implicate rad1 homologs in DNA damage–induced apoptosis in animals.
展开
关键词：
Animals Germ Cells Caenorhabditis elegans Endonucleases DNA-Binding Proteins Helminth Proteins Caenorhabditis elegans Proteins Dose-Response Relationship, Radiation Mutation Mitosis
DOI：
10.1016/S1097-2765(00)80438-4
被引量：
年份：
2000
Elsevier
(全网免费下载)
Elsevier
国家科技图书文献中心
(权威机构)
万方
Semantic Scholar
查看更多
掌桥科研
Semantic Scholar
(全网免费下载)
dx.doi.org
BioOne
Oxford Univ Press
NCBI
Cell Press
CAB Direct
Cell Press
(全网免费下载)
NCBI
Europe PMC
ResearchGate
(全网免费下载)
EureKaMag.com
(全网免费下载)
ResearchGate
Citeseer
(全网免费下载)
Citeseer
EBSCO
zora.uzh.ch
(全网免费下载)
onAcademic
lifesci.dundee.ac.uk
(全网免费下载)
zora.uzh.ch
genome.cshlp.org
discovery.dundee.ac.uk
bio.unc.edu
(全网免费下载)
osti.gov
(全网免费下载)
core.ac.uk
mysciencework.com
uncch.pure.elsevier.com
invenzone.com
labs.bio.unc.edu
(全网免费下载)
infona.pl
hw-f5-embor.highwire.org
emboj.embopress.org
scienceopen.com
lifesci.dundee.ac.uk
(全网免费下载)
core.ac.uk
(全网免费下载)
mendeley.com
pubfacts.com
repository.cshl.edu
molbiolcell.org
plantphysiol.org
bio.unc.edu
(全网免费下载)
www.socolar.com
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
Cell Press
(全网免费下载)
EureKaMag.com
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
labs.bio.unc.edu
(全网免费下载)
osti.gov
(全网免费下载)
lifesci.dundee.ac.uk
(全网免费下载)
core.ac.uk
(全网免费下载)
lifesci.dundee.ac.uk
(全网免费下载)
zora.uzh.ch
(全网免费下载)
bio.unc.edu
(全网免费下载)
bio.unc.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
