Multigenic Natural Variation Underlies Caenorhabditis elegans Olfactory Preference for the Bacterial Pathogen Serratia marcescens
摘要：
The nematodeCaenorhabditis eleganscan use olfaction to discriminate among different kinds of bacteria, its major food source. We asked how natural genetic variation contributes to choice behavior, focusing on differences in olfactory preference behavior between two wild-typeC. elegansstrains. The laboratory strainN2strongly prefers the odor ofSerratia marcescens, a soil bacterium that is pathogenic toC. elegans, to the odor ofEscherichia coli, a commonly used laboratory food source. The divergent Hawaiian strainCB4856has a weaker attraction toSerratiathan theN2strain, and this behavioral difference has a complex genetic basis. At least three quantitative trait loci (QTLs) from theCB4856Hawaii strain (HW) with large effect sizes lead to reducedSerratiapreference when introgressed into anN2genetic background. These loci interact and have epistatic interactions with at least two antagonistic QTLs from HW that increaseSerratiapreference. The complex genetic architecture of thisC. eleganstrait is reminiscent of the architecture of mammalian metabolic and behavioral traits.
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DOI：
10.1534/g3.113.008649
被引量：
年份：
2014
Semantic Scholar
掌桥科研
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