POLYMORPHOUS FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN THE MEDICINAL PREPARATIONS

阅读量:

32

申请(专利)号:

US202117563579

申请日期:

2021-12-28

公开/公告号:

US2022119403A1

公开/公告日期:

2022-04-21

申请(专利权)人:

ALFASIGMA S.P.A.

发明人:

GC ViscomiM CampanaD ConfortiniMM BarbantiD Braga

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国省代号:

IT

被引量:

45

摘要:

Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.

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