摘要：

Studies on the fusion of phospholipid vesicles have provided considerable insight into the molecular mechanism of membrane fusion and the role of specific molecules in this process. This simple and well-defined system has also helped in the development of fusion assays and the biophysical analysis of the fusion process. Early studies on fusion have been reviewed by Papahadjopoulos et al (1979) and Nir et al (1983 a ). Here we will discuss recent developments concerning the mechanism of membrane fusion induced by divalent cations and protons, and its modulation by the thermotropic properties of the phospholipid bilayer, monovalent cations and polyamines in the medium, and free fatty acids in the membrane.

展开