Methods for blocking or alleviating staphylococcal nasal colonization by intranasal application of monoclonal antibodies

This invention provides MAbs for blocking and alleviating nasal colonization by staphylococci and methods for their use in the anterior nares.

John Fitzgerald Kokai-Kun，Jeffrey Richard Stinson，Scott Michael Walsh，... - US

Synthesis of fused heterocycles: 1,2,3,4-tetrahydroisoquinolines and ring homologues via sulphonamidomethylation

The title heterocycles (3) have been obtained by a two-step synthesis; namely an initial intramolecular sulphonamidomethylation of N-aralkylsulphonamides (...

OO Orazi，Corral, Ren?e A.，Giaccio, H?ctor - 《Journal of the Chemical Society Perkin Transactions》

Methods of Diagnosis

Methods for determining whether an ADHD patient is suitable for treatment with a monoamine oxidase type B (MAO-B) inhibitor, and uses of MAO-B inhibitors in medicaments for treatment of ADHD. Nucleic acid probes and primer sequences usef...

AT Bruinvels - US

Oral composition for the treatment and prevention of bone loss

The invention is a composition and method for treating osteoporosis, bone loss and/or periodontal demineralization involving the oral administration of a formulation containing vanadium and ipriflavone which support an increase in bone m...

D Mckee - US

Antilipemic

Certain mono- and disubstituted-5-sulfamylbenzoic acids, many of which are novel, and their use in lowering blood lipid levels in mammals.

GF Helland - US

Cosmetic composition comprising N-ethyloxycarbonyl-4-amino-phenol and arbutin or its derivatives and/or ellagic acid or its derivatives

A depigmenting and/or lightening composition is provided, wherein the composition contains N-ethyloxycarbonyl-4-para-aminophenol and at least one depigmenting agent selected from arbutin and its derivatives and/or ellagic acid and its de...

V Chevalier，DM Pham - US

Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds

This invention is directed to compounds of formula I: ##STR1## wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. The...

RD Groneberg，KW Neuenschwander，SW Djuric，... - EP

Anticancer agent; antiarthritic agent

Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNFα-mediated diseases, including ...

DA Owen，JG Montana，JF Keily，... - US

Use of taurine for the treatment of alopecia

The invention relates to the use of taurine and/or hypotaurine and/or the acceptable salts thereof in an oral composition for the preparation of an oral composition that can be usef for the treatment and prevention of ageing of the pilos...

A Duranton，L Breton - EP

Hydroxamic and carboxylic acid derivatives

Compounds having therapeutic utility are of formula (I)

JG Montana，AD Baxter，DA Owen，... - US