NF-kappaB regulation in the immune system.
摘要：
The nuclear factor-kappaB (NF-kappaB)/REL family of transcription factors has a central role in coordinating the expression of a wide variety of genes that control immune responses. There has been intense scientific activity in the NF-kappaB field owing to the involvement of these factors in the activation and regulation of key molecules that are associated with diseases ranging from inflammation to cancer. In this review, we focus on our current understanding of NF-kappaB regulation and its role in the immune system and inflammatory diseases. We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications.
展开
关键词：
Immune System Animals Mice, Knockout Humans Mice Inflammation Protein-Serine-Threonine Kinases DNA-Binding Proteins NF-kappa B Signal Transduction
DOI：
10.1038/nri910
被引量：
年份：
2002
Taylor & Francis
Nature
(全网免费下载)
Nature
万方医学
Europe PMC
查看更多
Oxford Univ Press
NCBI
NCBI
ProQuest
mct.aacrjournals.org
oarsijournal.com
jem.rupress.org
jasn.asnjournals.org
go.galegroup.com
scienceopen.com
jlr.org
pubmed.com
science-open.com
ftp.palgrave-journals.com
mendeley.com
molbiolcell.org
jacionline.org
ajconline.org
fertstert.org
mcb.asm.org
jcs.biologists.org
ajpgi.physiology.org
iwaponline.com
eje-online.org
embor.embopress.org
cghjournal.org
Nature
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
