A Facile Method for the Synthesis of 3-Alkyloxindole
摘要：
Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3-alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH4.
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关键词：
arylation amination oxindoles alkylation Knoevenagel condensations carbonyl compounds conjugate reduction benzylamine 3-alkyloxindoles 3-alkenyloxindoles
DOI：
10.2174/157017812800167420
被引量：
年份：
2012
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