The most common chromosome change in 86 chronic B cell or T cell tumors: a 14q32 translocation.

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作者：

PC Nowell，EC Vonderheid，E Besa，JA Hoxie，JB Finan

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摘要：

Among 46 patients with chronic lymphocytic leukemia (CLL) (40 B cell, 6 T cell) and 40 patients with cutaneous T cell lymphoma (CTCL), a chromosomally abnormal neoplastic clone was identified in 43 cases. A translocation involving 14q32 was present in nine cases (five B-CLL, two T-CLL, two CTCL). The donor chromosomal site was 11q13 in four patients and 1q12, 4q25–27, 17q21–22, 18q21, and 22q11 in one case each. The next most frequent abnormalities were rearrangements involving 6q21–23 (four cases), and trisomy 12 (four cases, all B-CLL). In one CTCL patient, the t(11;14) translocation was present in one of three apparently unrelated T cell clones. Recent studies indicate that the selective advantage conferred by the 14q+ chromosome in B cell neoplasms appears to result from an oncogene being brought adjacent to a rearranged and transcriptionally active immunoglobulin heavy chain locus. The present findings suggest that similar mechanisms may operate in certain T cell neoplasms, athough the activating gene is not necessarily the same.

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关键词：

B-Lymphocytes T-Lymphocytes Chromosomes, Human, 1-3 Chromosomes, Human, 13-15 Humans Lymphoma Sezary Syndrome Skin Neoplasms Translocation, Genetic Aged