Functions and mechanisms of long noncoding RNAs in lung cancer

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摘要：

Long non-coding RNAs(lncRNAs) are non-coding RNAs that have transcript lengths exceeding 200 bp and do not have the capacity for protein coding because of having no open reading frame. In the human genome, lncRNAs play important regulatory roles in the process of epigenetic, transcription and post-transcription, so they have become the focus of research followed by microRNAs. The abnormal expression of lncRNAs in cancer usually represents different functions, such as the function of oncogenes or tumor suppressor genes, which promote or inhibit tumor growth. Lung cancer is a common malignant tumor with a five-year survival rate of 17%. Previous literature shows that MALAT1, H19, lincRNA p21, UCA1, and BC200 are closely related to the development of lung cancer. They could promote cancer growth, invasion and metastasis, apoptosis and induce drug resistance, and so on. This review aims to provide assistance in the diagnosis, treatment, and prognosis of lung cancer by clarifying the functions and mechanisms of lncRNAs.

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关键词：

lncRNA lung cancer gene expression gene regulation

DOI：

10.3969/j.issn.1000-8179.20130372

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2013