The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical.

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作者：

SK Dower，SR Kronheim，TP Hopp，M Cantrell，M Deeley，S Gillis，CS Henney，DL Urdal

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摘要：

Interleukin-1 (IL-1) is a factor that can induce proliferation of murine T lymphocytes 1,2 and can elicit a variety of other biological responses. These include bone resorption 3 , fibroblast proliferation 4 , acute phase protein release from hepatocytes 5 , cartilage breakdown 6 and fever 7 . This spectrum of activities is consistent with a role for IL-1 as a mediator of inflammation. Recently, sequence data have shown that there are at least two members of the IL-1 family; these distantly related proteins have been termed IL-1α and IL-1β 8–11 . We have found previously that both murine T cells and fibroblasts possess a relative molecular mass ( M r ) 80,000 (80K) plasma membrane receptor for human IL-1β 12,13 . We show here that the receptor for IL-1α on both murine and human cells is identical to that for IL-1β. This result raises the issue of what separation, if any, there might be between the biological activities of IL-1α and IL-1β.

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关键词：

Animals Mice, Inbred BALB C Humans Mice Cells, Cultured Cell Line Cell Membrane Receptors, Immunologic Kinetics Binding, Competitive