Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
摘要：
Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic malignancies. The latter are characterized, at least in some cases, by loss of heterozygosity (LOH) at the CBP locus. No such pathology was observed in wild-type or p300 heterozygous null mice of the same age and genetic background. Thus, a full complement of CBP, but not p300, is required for normal hematopoietic differentiation. These results also provide the first experimental evidence for the hypothesis that CBP has tumor-suppressing activity.
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关键词：
Animals Mice, Inbred C57BL Mice, Knockout Mice Spleen Hematologic Neoplasms Trans-Activators Nuclear Proteins Cell Transplantation Blotting, Southern
DOI：
10.1101/gad.14.3.272
被引量：
年份：
2000
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掌桥科研
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万方医学
NCBI
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