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Adipose tissue remodeling and obesity

来自 NCBI

阅读量：

319

作者：

K Sun，CM Kusminski，PE Scherer

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摘要：

To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion requires a highly coordinated response among many different cell types, including endothelial precursor cells, immune cells, and preadipocytes. There are therefore remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.

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关键词：

Animals Humans Mice Adipose Tissue Macrophages Endothelial Cells Extracellular Matrix Inflammation Weight Loss Obesity

DOI：

10.1172/JCI45887

被引量：

1688

年份：

2011

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来源期刊

Journal of Clinical Investigation
June 2011

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2013
被引量：320

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