Contribution of cohort studies in understanding HIV pathogenesis: Introduction of the GRIV cohort and preliminary results
摘要：
In the present paper we review studies performed on HIV-infected patients cohorts in order to understand AIDS disease development. The interplay between diverse factors such as the HIV envelope proteins, cellular co-receptors, the immune response with chemokines and cytokines production define the viral tropism, cytopathicity and progression of HIV disease. We present the trends of the research particularly in the domain concerning host genetics. In this context, we describe the GRIV cohort of fast and slow/non-progressors, and its use for understanding basic features of the yet unknown HIV pathogenesis mechanisms.
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关键词：
3 or 4 drug virostatic combinations drug rotation combination different sequences viral targets viral load decrease suppressor cell decrease cytotoxic cell increase unchanged CD4 cells
DOI：
10.1016/S0753-3322(97)89278-5
被引量：
年份：
1996
Elsevier
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Semantic Scholar
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EureKaMag.com
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Citeseer
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学术范
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griv.org
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