Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma.

来自 dx.doi.org

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257

作者：

HM Chen，YN Yu，JL Wang，YW Lin，X Kong，CQ Yang，L Yang，ZJ Liu，YZ Yuan，F Liu

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摘要：

Background: Accumulating evidence indicates that diet is one of the most important environmental factors involved in the progression from advanced colorectal adenoma (A-CRA) to colorectal cancer.Objective: We evaluated the possible effects of dietary fiber on the fecal microbiota of patients with A-CRA.Design: Patients with a diagnosis of A-CRA by pathological examination were enrolled in the A-CRA group. Patients with no obvious abnormalities or histopathological changes were enrolled in the healthy control (HC) group. Dietary fiber intake was assessed in all patients. Short-chain fatty acids (SCFAs) in feces were detected by gas chromatography. The fecal microbiota community was analyzed by 454 pyrosequencing based on 16S ribosomal RNA.Results: Lower dietary fiber patterns and consistently lower SCFA production were observed in the A-CRA group (n = 344). Principal component analysis showed distinct differences in the fecal microbiota communities of the 2 groups. Clostridium, Roseburia, and Eubacterium spp. were significantly less prevalent in the A-CRA group (n = 47) than in the HC group (n = 47), whereas Enterococcus and Streptococcus spp. were more prevalent in the A-CRA group (n = 47) (all P Conclusion: A high-fiber dietary pattern and subsequent consistent production of SCFAs and healthy gut microbiota are associated with a reduced risk of A-CRA. This trial was registered at www.chictr.org as ChiCTR-TRC-00000123. Am J Clin Nutr 2013;97:1044-52.

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关键词：

BUTYRATE-PRODUCING BACTERIA FOOD FREQUENCY QUESTIONNAIRE COLON-CANCER LARGE-BOWEL DIVERSITY ACID ECOLOGY RISK METABOLISM PROTECTION