A Mechanistic Design Principle for Protein Tyrosine Kinase Sensors: Application to a Validated Cancer Target
摘要：
A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein tyrosine kinases, as demonstrated by the acquisition of a fluorescent sensor for the extraordinarily demanding anaplastic lymphoma kinase.
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DOI：
10.1021/ol702675b
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年份：
2008
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来源期刊
Organic Letters
2008年
引用走势
2010
被引量：10
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