A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
摘要：
Nuclear transcription factors of the NF-κB/Rel family are inhibited by IκB proteins, which inactivate NF-κB by trapping it in the cell cytoplasm. Phosphorylation of IκBs marks them out for destruction, thereby relieving their inhibitory effect on NF-κB. A cytokine-activated protein kinase complex, IKK (for IκB kinase), has now been purified that phosphorylates IκBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-κB activation.
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关键词：
Hela Cells Humans Protein-Serine-Threonine Kinases Tumor Necrosis Factor-alpha NF-kappa B Inflammation Mediators Cloning, Molecular Enzyme Activation Amino Acid Sequence Substrate Specificity
DOI：
10.1038/41493
被引量：
年份：
1997
Springer
Nature
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Nature
掌桥科研
万方医学
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