Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels.
摘要：
A single intravascular injection of a cyclic peptide or monoclonal antibody antagonist of integrin α v β 3 disrupts ongoing angiogenesis on the chick chorioallantoic membrane (CAM). This leads to the rapid regression of histologically distinct human tumors transplanted onto the CAM. Induction of angiogenesis by a tumor or cytokine promotes vascular cell entry into the cell cycle and expression of integrin α v β 3 . After angiogenesis is initiated, antagonists of this integrin induce apoptosis of the proliferative angiogenic vascular cells, eaving preexisting quiescent blood vessels unaffected. We demonstrate therefore that ligation of integrin α v β 3 is required for the survival and maturation of newly forming blood vessels, an event essential for the proliferation of tumors.
展开
关键词：
Blood Vessels Allantois Chorion Tumor Cells, Cultured Chick Embryo Animals Humans Neoplasms Neovascularization, Pathologic Integrins
DOI：
10.1016/0092-8674(94)90007-8
被引量：
年份：
1994
Elsevier
BMJ
Semantic Scholar
万方医学
dx.doi.org
查看更多
Oxford Univ Press
Europe PMC
NCBI
Cell Press
(全网免费下载)
Cell Press
NCBI
ResearchGate
EBSCO
hyper.ahajournals.org
embojnl.embopress.org
science-open.com
onAcademic
ajpheart.physiology.org
mct.aacrjournals.org
scienceopen.com
molbiolcell.org
mendeley.com
pharmrev.aspetjournals.org
reproduction-online.org
perspectivesinmedicine.cshlp.org
readcube.com
iovs.org
mcponline.org
Cell Press
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
