Identification of a serotonin/glutamate receptor complex implicated in psychosis
摘要：
The psychosis associated with schizophrenia is characterized by alterations in sensory processing and perception. Some antipsychotic drugs were identified by their high affinity for serotonin 5-HT2A receptors (2AR). Drugs that interact with metabotropic glutamate receptors (mGluR) also have potential for the treatment of schizophrenia. The effects of hallucinogenic drugs, such as psilocybin and lysergic acid diethylamide, require the 2AR and resemble some of the core symptoms of schizophrenia. Here we show that the mGluR2 interacts through specific transmembrane helix domains with the 2AR, a member of an unrelated G-protein-coupled receptor family, to form functional complexes in brain cortex. The 2AR-mGluR2 complex triggers unique cellular responses when targeted by hallucinogenic drugs, and activation of mGluR2 abolishes hallucinogen-specific signalling and behavioural responses. In post-mortem human brain from untreated schizophrenic subjects, the 2AR is upregulated and the mGluR2 is downregulated, a pattern that could predispose to psychosis. These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis.
展开
关键词：
Animals Humans Mice Brain Cells, Cultured Cell Line Multiprotein Complexes Hallucinogens Receptors, Metabotropic Glutamate Receptor, Serotonin, 5-HT2A
DOI：
10.1038/nature06612
被引量：
年份：
2008
Nature
Springer
Nature
(全网免费下载)
国家科技图书文献中心
(权威机构)
EBSCO
查看更多
Semantic Scholar
(全网免费下载)
万方医学
Semantic Scholar
掌桥科研
Ingenta
dx.doi.org
NCBI
NCBI
(全网免费下载)
Oxford Univ Press
NCBI
Europe PMC
(全网免费下载)
Europe PMC
JBC
adsabs.harvard.edu
ProQuest
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
EBSCO
phy.ucsf.edu
(全网免费下载)
scienceopen.com
keck.ucsf.edu
(全网免费下载)
frontiersin.org
deepdyve.com
jcs.biologists.org
pubget.com
core.ac.uk
ftp.palgrave-journals.com
keck.ucsf.edu
(全网免费下载)
neuroscience.ucsf.edu
(全网免费下载)
pharmrev.aspetjournals.org
ukpmc.ac.uk
eprints.gla.ac.uk
f1000.com
jme.endocrinology-journals.org
ideas.repec.org
onAcademic
readcube.com
emboj.embopress.org
vmdev1.eprints.org
pubfacts.com
mysciencework.com
erowid.org
core.kmi.open.ac.uk
mendeley.com
addgene.org
钛学术
钛学术
(全网免费下载)
Nature
(全网免费下载)
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
neuroscience.ucsf.edu
(全网免费下载)
钛学术
(全网免费下载)
phy.ucsf.edu
(全网免费下载)
keck.ucsf.edu
(全网免费下载)
keck.ucsf.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
