MIF as a glucocorticoid-induced modulator of cytokine production.
摘要：
GLUCOCORTICOID hormones are important for vital functions and act to modulate inflammatory and immune responses 1,2 . Yet, in contrast to other hormonal systems, no endogenous mediators have been identified that can directly counter-regulate their potent anti-inflammatory and immunosuppressive properties. Recent investigations of the protein macrophage migration inhibitory factor (MIF), which was discovered originally to be a T-lymphocyte-derived factor 3,4 , have established it to be a pro-inflammatory pituitary and macrophage cytokine and a critical mediator of septic shock 5–7 . Here we report the unexpected finding that low con-centrations of glucocorticoids induce rather than inhibit MIF production from macrophages. MIF then acts to override gluco-corticoid-mediated inhibition of cytokine secretion by lipopoly-saccharide (LPS)-stimulated monocytes and to overcome glucocorticoid protection against lethal endotoxaemia. These observations identify a unique counter-regulatory system that functions to control inflammatory and immune responses.
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关键词：
T-Lymphocytes Cell Line Macrophages Animals Mice, Inbred BALB C Humans Mice Rats Rats, Sprague-Dawley Shock, Septic
DOI：
10.1038/377068a0
被引量：
年份：
1995
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