UNC1062, a new and potent Mer inhibitor
摘要:
Discovery of pyazolopyrimidine sulfonamides as potent and selective Mer inhibitors.UNC1062 selectively inhibits Mer both in purified enzymes and intact cell systems.UNC1062 inhibits the colony formation of multiple tumor cell lines in soft agar.The anti-tumor activity of UNC1062 further validates Mer as a therapeutic target.
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关键词:
Mer inhibitors Pyrazolopyrimidines Sulfonamides Leukemia Non-small cell lung cancer Glioblastoma
DOI:
10.1016/j.ejmech.2013.03.035
被引量:
年份:
2013























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