B cell receptor signal strength determines B cell fate
摘要：
B cell receptor ()-mediated antigen recognition is thought to regulate . signal strength may also influence B cell fate decisions. Here, we used the protein LMP2A as a constitutively active surrogate to study the contribution of signal strength in . carrying a targeted replacement of by LMP2A leading to high or low expression of the LMP2A protein developed B-1 or follicular and marginal zone B cells, respectively. These data indicate that signal strength, rather than antigen specificity, determines mature B cell fate. Furthermore, spontaneous germinal centers developed in gut-associated lymphoid tissue of LMP2A , indicating that microbial antigens can promote germinal centers independently of -mediated antigen recognition.
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关键词：
Animals Mice Germinal Center Peyer' s Patches B-Lymphocytes Cells, Cultured Receptors, Antigen, B-Cell Gene Targeting Signal Transduction
DOI：
10.1038/ni1036
被引量：
年份：
2004
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