The production of leukaemia inhibitory factor by human endometrium: presence in uterine flushings and production by cells in culture.

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作者：

SM Laird，EM Tuckerman，CF Dalton，BC Dunphy，TC Li，X Zhang

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摘要：

The concentration of inhibitory factor () was measured in uterine flushings obtained from normal fertile women, from women with unexplained and from women who suffered . In normal fertile women, was not detected in flushings obtained on days luteinizing hormone (LH)+0 to LH+6 of the cycle, but concentrations gradually increased from day LH+7 to a maximum at day LH+12. The amount of in flushings obtained from women with unexplained was significantly lower than in those from normal fertile women on day LH+10 (P < 0.05). The production of by cultured epithelial and stromal cells was also investigated. was not detectable in the supernatants of cultured stromal cells. Basal production by epithelial cells varied according to the stage in the cycle at which the biopsy was taken. Significantly more was produced by epithelial cells from late proliferative and early secretory endometrium compared with amounts produced by cells from early proliferative (P < 0.001) and late secretory (P < 0.01) endometrium. High doses of and caused a small decrease in epithelial cell production: the combined effect of and (P < 0.01) was greater than the effect of either steroid alone (P < 0.05). The results show, for the first time, the capability of endometrium to produce in vivo. The fact that maximum concentrations are present at implantation and that decreased concentrations occur in women with unexplained suggest the importance of this cytokine in .

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关键词：

human endometrium leukaemia inhibitory factor steroids

DOI：

10.1093/humrep/12.3.569

被引量：

716

年份：

1997