Concise Asymmetric Synthesis of Orthogonally Protected syn- and anti-1,3-Aminoalcohols
摘要：
Novel chiral binfunctional reagents V and ent-V undergo asymmetric aldehyde allylation followed by Ir(I)-catalyzed enantioselective allylic amidation to give orthogonally protected syn- and anti-1,3-aminoalcohols with complete control of absolute and relative stereochemistry. The Mitsunobu reaction of the initial homoallylic alcohol products followed by Ir(I)-catalyzed enantioselective allylic amidation provides orthogonally protected syn- and anti-1,3-diamine derivatives in high yields and with excellent stereoselectivities.
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关键词：
amino alcohols (acyclic compounds) diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
DOI：
10.1021/ol303371u
被引量：
年份：
2013
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