Cytotoxicity, antioxidant, and antimicrobial activities of novel 2-quinolone derivatives derived from coumarin
摘要：
Coumarins are important and useful compounds with diverse pharmacological properties. New coumarin derivatives namely N -aminoquinoline-2-one 1 , 1-((4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methyleneamino)quinolin-2(1H)-one 2 and 1,1′-(1E,1′E)-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(azan-1-yl-1-ylidene)diquinolin-2(1H)-one 3 , were synthesized and characterized by UV–Vis, FT-IR, and NMR spectra in addition of elemental analysis. The synthesized compounds ( 2 and 3 ) show considerable anticancer activity against HEp-2 cell line. Synthesized compounds ( 2 and 3 ) were tested against selected types of microbial organisms and showed significant activities. The free-radical scavenging activity of synthesized compounds ( 2 and 3 ) have been determined by their interaction with the stable free-radical 1,1-diphenyl-2-picrilhydrazyl (DPPH) and all the compounds have shown encouraging antioxidant activities.
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DOI：
10.1007/s11164-011-0371-2
被引量：
年份：
2012
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