Insulin-induced gene: A new regulator in lipid metabolism

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摘要：

Insulin-induced genes (Insigs) including Insig-1 and Insig-2, are proteins that mediate sterol regulation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase). Insigs perform distinct tasks in the regulation of these effectors: they promote the endoplasmic reticulum (ER) retention of SCAP, but ubiquitin-mediated degradation of HMG-CoA reductase. Through these activities, Insig-1 and Insig-2 influence cholesterol metabolism, lipogenesis, and glucose homeostasis in diverse tissues such as adipose tissue and liver. In this article, we focus on the functions, expression and regulation, gene polymorphisms of Insigs, and their deficiency with diseases.Research highlights? Insigs play a novel role in cholesterol homeostasis. ? Insigs are required for lipogenesis. ? INSIGs genetic polymorphisms are associated with obesity and hypercholesterolaemia. ? INSIGs genetic deficiency leads to metabolic diseases.

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关键词：

Insigs SCAP HMG-CoA reductase Cholesterol metabolism Lipogenesis Glucose homeostasis Disease

DOI：

10.1016/j.peptides.2010.07.020

被引量：

153

年份：

2010