Antitumor Potency of Ascorbic, Dehydroascorbic or 2, 3-Diketogulonic Acid and Their Action on Deoxyribonucleic Acid
摘要：
Three nutritively significant enediol compounds mentioned in above title can inhibit sarcoma-180 growth. The inhibition by ascorbic acid is enhanced by cupric ions. These enediols depolymerize DNA, particularly in co-operation with copper. Dehydroascorbic acid is able to break denatured DNA and to bring about single strand scission for native one. A mixture of dehydroascorbate and Cu decomposes apurinic acid and liberates deoxy-cytidylic acid from it. Only the oligo-form pf pyrimidine tetra- and penta-nucleotides is disintegrated by this reagent. The results were briefly discussed in relation to metabolic carcinostasis and to the formulation of Yamafuji effect causing cellular differentiation and anomalization.
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DOI：
10.1007/BF00304282
被引量：
年份：
1971
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