PUMA, a novel proapoptotic gene, is induced by p53.
摘要：
The p53 tumor-suppressor protein functions as a transcriptional activator, and several p53-inducible genes that play a role in the induction of apoptosis in response to p53 have been described. We have identified a novel gene named PUMA ( p53 upregulated modulator of apoptosis) as a target for activation by p53. This gene encodes two BH3 domain–containing proteins (PUMA-α and PUMA-β) that are induced in cells following p53 activation. PUMA-α and PUMA-β show similar activities; they bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1–dependent pathway.
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关键词：
Humans Mitochondria Cell Line Tumor Cells, Cultured Cytochrome c Group Enzyme Precursors Caspases DNA Helminth Proteins Proto-Oncogene Proteins c-bcl-2
DOI：
10.1016/S1097-2765(01)00214-3
被引量：
年份：
2001
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