bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship.

来自 dx.doi.org

喜欢 0

阅读量：

104

作者：

A Strasser，AW Harris，S Cory

展开

摘要：

Early death is the fate of most developing T lymphocytes. Because bcl-2 can promote cell survival, we tested its impact in mice expressing an E mu-bcl-2 transgene within the T lymphoid compartment. The T cells showed remarkably sustained viability and some spontaneous differentiation in vitro. They also resisted killing by lymphotoxic agents. Although total T cell numbers and the rate of thymic involution were unaltered, the response to immunization was enhanced, consistent with reduced death of activated T cells. No T cells reactive with self-superantigens appeared in the lymph nodes, but an excess was found in the thymus. These observations, together with previous findings on B cells, suggest that modulated bcl-2 expression is a determinant of life and death in normal lymphocytes.

展开

关键词：

Animals Mice, Inbred Strains Mice Lymph Nodes T-Lymphocyte Subsets T-Lymphocytes Dexamethasone Tetradecanoylphorbol Acetate Sodium Azide Ionomycin