Resolution of a tetrahydrofuran ester by Candida rugosa lipase (CRL) and an examination of CRL's stereochemical preference in organic media

阅读量:

41

作者:

MauriceC.R.FranssenandHugoJongejanandHuubKooijmanand

展开

摘要:

Crude lipase from Candida rugosa (CRL) is able to resolve the C3-stereoisomers of the furo[2,3b]furan building block methyl 2-methoxytetrahydrofuran-3-carboxylate 6 by alcoholysis using n-butanol in octane. The reaction is not affected by the configuration at C2. The absolute configuration of the product 7 is 3S as determined by X-ray analysis of the crystalline derivative 14. The stereochemical outcome of the reaction is compared to the active site model derived by the group of Kazlauskas (Ahmed et al., Biocatalysis9 (1994), 209). Evidence is presented for the validity of this model for CRL-catalyzed alcoholysis, esterification and acidolysis reactions in organic media.

展开

DOI:

10.1016/0957-4166(96)00033-X

被引量:

40

年份:

1996

通过文献互助平台发起求助,成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证,认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献,1~5分钟即可下载全文,部分资源由于网络原因可能需要更长时间,请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

来源期刊

引用走势

1997
被引量:9

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用