摘要：

Okadaic acid (OA; C 44 H 66 O 13 ) is a polyether derivative of a C 38 fatty acid first isolated from marine sponges of the genus Halichondria (Tachibana et al. 1981). It is thought to be synthesized by marine diflagellates and to accumulate in the other marine organisms such as sponges and shellfishes which feed on them (Yasumoto et al. 1985). Physiologically, OA has been known to have a marked contractile effect on smooth muscles (Shibata et al. 1982) and heart muscle (Kodama et al. 1986). Recent results strongly suggest that these contractile effects are due to the inhibitory action of OA on the intracellular protein phosphatase activity (Takai et al. 1987; Bialojan et al. 1988; Hescheler et al. 1988; Bialojan & Takai, 1988).

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