Total synthesis of forskolin — Part II
摘要：
The further elaboration of the key-intermediate 5 into forskolin 1 has been achieved via two different routes. Key features of this new total synthesis are: 1) the stereospecific formation of the 6β, 7β, 8α-triol via the BF 3 Et 2 O assisted opening of the epoxy carbamate 8 ; 2) use of the 8α, 11-di- t -butylsilylene ketal for the specific protection of the 6β, 7β-diol, from the tetrol 10 A ; two new sequences for the formation of the dihydro-γ-pyrone ring in high overall yield from 23 ; 4) the stereoselective divinyl cuprate conjugate α-addition on the dihydro-γ-pyrone 16 or 28 , in the presence of BF 3 Et 2 O, with the stereochemistry required for forskolin synthesis.
展开
DOI：
10.1016/0040-4039(95)02364-X
被引量：
年份：
1996
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
