Delayed metastases in cancer of the breast

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摘要：

1. 1. Cases of breast cancer with metastasis after radical mastectomy have been tabulated with reference to various details. 2. 2. On statistical evaluation of periods elapsed between operation and recurrence in breast cancer, no evidence of qualitative difference between cases with long and with short latency was found. 3. 3. On surveying various groups of our material it was found that in the average the shorter periods of latencies occur in cases with rapid preoperative growth, presence of metastasis at time of operation and manifestation of the metastasis in the region of the primary growth. No influence of the age and the histological structure (small duct and large duct cancers) was found. 4. 4. On comparison of cases of breast cancer with delayed metastases compiled from the literature no trait common to all these cases was found. 5. 5. One case with the following features suggesting a very low degree of malignancy was extensively described: (1) A period of more than fifteen years elapsed between operation and manifestation of the recurrence. (2) No clinical symptoms appeared until shortly before death in spite of the evidence that the new growth must have been present for a long time. (3) There was no functional impairment of two nerves in spite of their being surrounded by tumor masses. (4) There was huge local development without spread to distant points.

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DOI：

10.1016/S0002-9610(42)90219-8

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年份：

1942