The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation
摘要：
The inherited human disease tuberous sclerosis, characterized by hamartomatous tumors, results from mutations in either TSC1 or TSC2. We have characterized mutations in the Drosophila Tsc1 and Tsc2/ gigas genes. Inactivating mutations in either gene cause an identical phenotype characterized by enhanced growth and increased cell size with no change in ploidy. Overall, mutant cells spend less time in G1. Coexpression of both Tsc1 and Tsc2 restricts tissue growth and reduces cell size and cell proliferation. This phenotype is modulated by manipulations in cyclin levels. In postmitotic mutant cells, levels of Cyclin E and Cyclin A are elevated. This correlates with a tendency for these cells to reenter the cell cycle inappropriately as is observed in the human lesions.
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关键词：
Animals Humans Tuberous Sclerosis Repressor Proteins DNA Proteins Cyclin A Cyclin E Insect Proteins Luminescent Proteins
DOI：
10.1016/S0092-8674(01)00332-4
被引量：
年份：
2001
Elsevier
Elsevier
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Semantic Scholar
Semantic Scholar
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万方医学
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